The Use of Antibiotics for Ventilator-Associated Pneumonia in the MIMIC-IV Database

Frontiers in Pharmacology

Li Li¹  Shuna Li¹  Aozi Feng¹  Rui Yang¹  Tao Huang¹  Ningxia He¹  Liying Huang¹  Wei Huang²  Longbin Shen³  Jun Lyu⁴  Hui Liu⁵ 

[1] Department of Clinical Research, The First Affiliated Hospital of Jinan University, Guangzhou, China;Department of Hepatobiliary Surgery II, MeiZhou People’s Hospital, Meizhou, China;Department of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, China;Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Informatization, Guangzhou, China;Intensive Care Unit, The First Affliated Hospital of Jinan University, Guangzhou, China;

关键词: ventilator-associated pneumonia;    antibiotics;    pathogenic bacteria;    MIMIC-IV database;    resistance rate;   

DOI  :  10.3389/fphar.2022.869499

来源: DOAJ

【 摘 要 】

Purpose: By analyzing the clinical characteristics, etiological characteristics and commonly used antibiotics of patients with ventilator-associated pneumonia (VAP) in intensive care units (ICUs) in the intensive care database. This study aims to provide guidance information for the clinical rational use of drugs for patients with VAP.Method: Patients with VAP information were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database, including their sociodemographic characteristics, vital signs, laboratory measurements, complications, microbiology, and antibiotic use. After data processing, the characteristics of the medications used by patients with VAP in ICUs were described using statistical graphs and tables, and experiences were summarized and the reasons were analyzed.Results: This study included 2,068 patients with VAP. Forty-eight patient characteristics, including demographic indicators, vital signs, biochemical indicators, scores, and comorbidities, were compared between the survival and death groups of VAP patients. Cephalosporins and vancomycin were the most commonly used. Among them, fourth-generation cephalosporin (ForGC) combined with vancomycin was used the most, by 540 patients. First-generati49n cephalosporin (FirGC) combined with vancomycin was associated with the highest survival rate (86.7%). More than 55% of patients were infected with Gram-negative bacteria. However, patients with VAP had fewer resistant strains (<25%). FirGC or ForGC combined with vancomycin had many inflammation-related features that differed significantly from those in patients who did not receive medication.Conclusion: Understanding antibiotic use, pathogenic bacteria compositions, and the drug resistance rates of patients with VAP can help prevent the occurrence of diseases, contain infections as soon as possible, and promote the recovery of patients.

【 授权许可】

Unknown