Assessment of Quality in Osteoporotic Human Trabecular Bone and Its Relationship to Mechanical Properties

Applied Sciences

Gerardo Presbítero¹  Ana Arizmendi-Morquecho²  David Gutiérrez³  Wendy Ruth Lemus-Martínez³  Pedro García⁴  José Félix Vilchez⁴ 

[1] Centro de Ingeniería y Desarrollo Industrial (CIDESI), Sede Nuevo León, Apodaca 66600, Mexico;Centro de Investigación en Materiales Avanzados S. C. (CIMAV), Unidad Monterrey, Apodaca 66628, Mexico;Centro de Investigación y de Estudios Avanzados (Cinvestav), Unidad Monterrey, Apodaca 66600, Mexico;Facultad de Medicina, Universidad Autónoma de Nuevo León (UANL), Monterrey 64460, Mexico;

关键词: trabecular bone;    bone mineral density;    micro-CT;    bone quality parameters;    osteoporosis;   

DOI  :  10.3390/app11125479

来源: DOAJ

【 摘 要 】

We propose an experimental technique for the estimation of quality parameters of post-mortem human bone samples with signs of osteoporosis. Since we were interested in characterizing bone microstructure by evaluating porosity, trabecular thickness, and space, we obtained reference values of those parameters for some of our samples through micro-computerized tomography (micro-CT). Nevertheless, as such technology is not widely available, here we used a 2D imaging approximation of those quality parameters. We based our estimation on simple digital microscopy and calibrated to ensure a percentage of similarity higher than 95% in comparison to those values achieved through micro-CT. Additionally, we subjected our samples to mechanical testing to obtain a complete characterization of our samples and to provide a preliminary assessment of the possible relationship between clinical tests of bone mineral density (BMD) and bone quality parameters. Our results show that BMD may have very low specificity in the assessment of the authentic microstructure of bone, then a broader analysis of quality parameters is required to enhance the reliability of future osteoporosis diagnosis technologies.

【 授权许可】

Unknown