Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Frontiers in Cardiovascular Medicine

Annemiek Dickhout¹  Rory R. Koenen² 

[1] Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, Netherlands;Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, Munich, Germany;

关键词: microparticle;    atherosclerosis;    vascular remodeling;    diagnostic;    platelet;    endothelial cell;   

DOI  :  10.3389/fcvm.2018.00113

来源: DOAJ

【 摘 要 】

The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.

【 授权许可】

Unknown