A peculiar case of psychosis: anti-NMDAr encephalitis

International Journal of Emergency Medicine

Lamia Kouba¹  Dalia Alhosain² 

[1] Department of Dermatology, Damascus University Hospitals;Department of Internal Medicine, Damascus University Hospitals;

关键词: Anti-NMDA receptor encephalitis;    Herpes simplex virus;    Psychosis;    Pregnancy;    Case report;   

DOI  :  10.1186/s12245-021-00389-y

来源: DOAJ

【 摘 要 】

Abstract Background Psychosis in pregnancy is rare and could be life-threatening. It requires prompt evaluation and proper management accordingly. Anti-N-methyl-d-aspartate receptor (anti-NMDAr) encephalitis following herpes simplex virus (HSV) infection is a rare cause of psychosis during pregnancy. Case presentation A 20-year-old woman at 18 weeks gestation presented with agitation and a 3-day history of hallucinations. She had a prior hospitalization for HSV encephalitis 6 weeks before. Her laboratory workup was unremarkable except for positive anti-NMDAr antibodies in the CSF. The patient was treated with high-dose corticosteroids and plasmapheresis, and she was discharged 2 weeks later fully recovered. Conclusions Anti-NMDAr encephalitis can be the culprit behind a new-onset of psychosis in pregnancy. Early diagnosis and treatment are crucial.

【 授权许可】

Unknown