Maternal Ambient Exposure to Atmospheric Pollutants during Pregnancy and Offspring Term Birth Weight in the Nationwide ELFE Cohort

International Journal of Environmental Research and Public Health

François Ducroz¹  Fabrice Dugay²  Emmanuel Rivière³  Julien Bernard³  Anne Laborie⁴  Jérôme Cortinovis⁵  Agnès Hulin⁶  Pierre-Yves Robic⁷  Jonathan Virga⁸  Itai Kloog⁹  Joel Schwartz^1,10  Marie Cheminat^1,11  Marie-Aline Charles^1,11  Cécile Zaros^1,11  Laure Malherbe^1,12  Ludivine Launay^1,13  Emie Seyve^1,14  Marion Ouidir^1,14  Valérie Siroux^1,14  Johanna Lepeule^1,14  Rémy Slama^1,14 

[1] AIR Pays-de-la-Loire, 44300 Nantes, France;AIRPARIF, 75004 Paris, France;ASPA, ATMO Grand Est, 67300 Schiltigheim, France;ATMO France, 75004 Paris, France;ATMO Normandie, 76000 Rouen, France;ATMO Nouvelle-Aquitaine, 33000 Bordeaux, France;ATMO Occitanie, 31330 Toulouse, France;ATMO PACA, 13006 Marseille, France;Department of Geography and Environmental Development, Ben-Gurion University of the Negev, Beer Sheva P.O. Box 653, Israel;Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA;Ined-Inserm-EFS Joint Unit ELFE, 75020 Paris, France;National Institute for Industrial Environment and Risks (INERIS), 60550 Verneuil en Halatte, France;U1086 INSERM-UCN ‘Anticipe’, 14000 Caen, France;Univ. Grenoble Alpes, Inserm, CNRS, IAB, 38000 Grenoble, France;

关键词: air pollution;    term birth weight;    spatial autocorrelation;    propensity score;    doubly robust;   

DOI  :  10.3390/ijerph18115806

来源: DOAJ

【 摘 要 】

Background: Studies have reported associations between maternal exposure to atmospheric pollution and lower birth weight. However, the evidence is not consistent and uncertainties remain. We used advanced statistical approaches to robustly estimate the association of atmospheric pollutant exposure during specific pregnancy time windows with term birth weight (TBW) in a nationwide study. Methods: Among 13,334 women from the French Longitudinal Study of Children (ELFE) cohort, exposures to PM_2.5, PM₁₀ (particles < 2.5 µm and <10 µm) and NO₂ (nitrogen dioxide) were estimated using a fine spatio-temporal exposure model. We used inverse probability scores and doubly robust methods in generalized additive models accounting for spatial autocorrelation to study the association of such exposures with TBW. Results: First trimester exposures were associated with an increased TBW. Second trimester exposures were associated with a decreased TBW by 17.1 g (95% CI, −26.8, −7.3) and by 18.0 g (−26.6, −9.4) for each 5 µg/m³ increase in PM_2.5 and PM₁₀, respectively, and by 15.9 g (−27.6, −4.2) for each 10 µg/m³ increase in NO₂. Third trimester exposures (truncated at 37 gestational weeks) were associated with a decreased TBW by 48.1 g (−58.1, −38.0) for PM_2.5, 38.1 g (−46.7, −29.6) for PM₁₀ and 14.7 g (−25.3, −4.0) for NO₂. Effects of pollutants on TBW were larger in rural areas. Conclusions: Our results support an adverse effect of air pollutant exposure on TBW. We highlighted a larger effect of air pollutants on TBW among women living in rural areas compared to women living in urban areas.

【 授权许可】

Unknown