The safety and efficacy of Glubran 2 as biliostatic agent in liver resection

Infectious Agents and Cancer

Andrea Belli¹  Mauro Piccirillo¹  Raffaele Palaia¹  Francesco Izzo¹  Vittorio Albino¹  Antonio Avallone²  Guglielmo Nasti²  Fabiana Tatangelo³  Roberta Fusco⁴  Vincenza Granata⁴  Renato Patrone⁵ 

[1] Department Corp-S Care and Research of Cancer of the Abdominal District, Hepatobiliary Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – Napoli”;Department Corp-S Care and Research of Cancer of the Abdominal District, Oncology Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS Napoli”;Department of Support to Cancer Pathways Diagnostics Area, Pathology and Cytopathology Unit, “Istituto Nazionale Tumori IRCCS Fondazione G. Pascale – IRCCS Napoli”;Department of Support to Cancer Pathways Diagnostics Area, Radiology Unit, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”;PhD ICTH, University Federico II;

关键词: Liver metastases;    Bile duct injury;    Hepatic resection;    Chemotherapy;    Efficacy;   

DOI  :  10.1186/s13027-021-00358-3

来源: DOAJ

【 摘 要 】

Abstract Background Biloma, an encapsulated collection of bile outside the biliary tree, supported by a predominantly iatrogenic biliary fistula, and bile likeage are two of the most important surgical complications after liver resection. We, hypothesized to conduct a project aimed to prevent, or reduce, the formation of biloma or biliary fistula applying on the hepatic resection area the cyanoacrylate glue (Glubran2). Methods We searched in our surgical database all patients underwent liver resection for mCRC from January 2013 to December 2018 and we found a total of 510 patients. 205 patients for Group A (study population: included patients in which we have used Glubran2 during surgical procedure) and 113 patients for Group B (control group), were enrolled. Results In both Groups no patients died during hospitalization and the 30-day mortality was 0 %. During follow-up in Group A, a biliary fistula was found in 2 patients (1 %) versus 3 patients in the Group B (2,6 %). In patients enrolled in Group A no adverse event were reported relate to the use of Glubran2. Conclusions It is possible to affirm that the use of Glubran2 as biliostatic agent after liver resection is useful to prevent bile leakage complication and biloma formation and its use demonstrated to be safe and feasible during liver surgery.

【 授权许可】

Unknown