Long-term potentiation at CA3-CA1 hippocampal synapse with special emphasis on aging, disease, and stress

Frontiers in Aging Neuroscience

Ashok eKumar¹ 

[1] University of Florida;

关键词: Aging;    Hippocampus;    Long-Term Potentiation;    stress;    afterhyperpolarization;   

DOI  :  10.3389/fnagi.2011.00007

来源: DOAJ

【 摘 要 】

Synaptic plasticity in the mammalian central nervous system has been the subject of intense investigation for the past four decades. Long-term potentiation (LTP), a major reflection of synaptic plasticity, is an activity-driven long-lasting increase in the efficacy of excitatory synaptic transmission following the delivery of a brief, high-frequency train of electrical stimulation. LTP is regarded as a principal candidate for the cellular mechanisms involved in learning and offers an attractive hypothesis of how memories are constructed. There are a number of exceptional full-length reviews published on LTP; the current review intends to present an overview of the research findings regarding hippocampal LTP with special emphasis on aging, diseases, and psychological insults.

【 授权许可】

Unknown