Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction

BMC Neuroscience

Kenjiro Ono¹  Masaki Yoshida²  Yuri Masaoka³  Yumika Kokudai³  Masahiko Izumizaki³  Natsuko Iizuka³  Shotaro Kamijo³  Motoyasu Honma³  Sayaka Wada³  Yuki Uchida³  Satomi Kubota³  Akira Yoshikawa⁴  Masahiro Ida⁵  Satoshi Yano⁶  Nobuyoshi Koiwa⁷  Haruko Sugiyama⁸ 

[1] Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan;Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan;Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, 142-8555, Tokyo, Japan;Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, 142-8555, Tokyo, Japan;School of Nursing and Rehabilitation Sciences, Showa University, Yokohama, Japan;Department of Radiology, Stroke Center, Ebara Tokyo Hospital, Tokyo, Japan;Division of Neurology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan;Human Arts and Sciences Research Center, University of Human Arts and Sciences, Saitama, Japan;Sensory Science Research, Kao Corporation, Tokyo, Japan;

关键词: Cognitive dysfunction;    Wisconsin card sorting test;    Aging;    Hippocampus;    Superior frontal gyrus;   

DOI  :  10.1186/s12868-021-00680-x

来源: Springer

【 摘 要 】

BackgroundCognitive function declines with age and has been shown to be associated with atrophy in some brain regions, including the prefrontal cortex. However, the details of the relationship between aging and cognitive dysfunction are not well understood.MethodsAcross a wide range of ages (24- to 85-years-old), this research measured the gray matter volume of structural magnetic resonance imaging data in 39 participants, while some brain regions were set as mediator variables to assess the cascade process between aging and cognitive dysfunction in a path analysis.ResultsPath analysis showed that age affected the left hippocampus, thereby directly affecting the left superior frontal gyrus. Furthermore, the gyrus directly affected higher order flexibility and maintenance abilities calculated as in the Wisconsin card sorting test, and the two abilities affected the assessment of general cognitive function.ConclusionOur finding suggests that a cascade process mediated by the left hippocampus and left superior frontal gyrus is involved in the relationship between aging and cognitive dysfunction.

【 授权许可】

CC BY