Estrogen-Related Receptor Alpha: An Under-Appreciated Potential Target for the Treatment of Metabolic Diseases

International Journal of Molecular Sciences

BrijeshKumar Singh¹  PaulMichael Yen¹  Madhulika Tripathi¹ 

[1] Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore 169857, Singapore;

关键词: estrogen-related receptor alpha;    mitophagy;    mitochondrial turnover;    metabolic diseases;    non-alcoholic fatty liver disease (nafld);    adipogenesis;    adaptive thermogenesis;   

DOI  :  10.3390/ijms21051645

来源: DOAJ

【 摘 要 】

The estrogen-related receptor alpha (ESRRA) is an orphan nuclear receptor (NR) that significantly influences cellular metabolism. ESRRA is predominantly expressed in metabolically-active tissues and regulates the transcription of metabolic genes, including those involved in mitochondrial turnover and autophagy. Although ESRRA activity is well-characterized in several types of cancer, recent reports suggest that it also has an important role in metabolic diseases. This minireview focuses on the regulation of cellular metabolism and function by ESRRA and its potential as a target for the treatment of metabolic disorders.

【 授权许可】

Unknown