Lipids around the Clock: Focus on Circadian Rhythms and Lipid Metabolism

Biology

Davide Gnocchi²  Matteo Pedrelli²  Eva Hurt-Camejo¹  Paolo Parini² 

[1] Strategy and Externalization, CVMD iMED, AstraZeneca, R&D, Mölndal, SE-431 83, Sweden; E-Mails:;Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet at Karolinska University Hospital Huddinge, Stockholm, 14186, Sweden; E-Mails:

关键词: circadian clock;    central oscillator;    peripheral oscillators;    lipid metabolism;    lipid transport;    metabolic diseases;   

DOI  :  10.3390/biology4010104

来源: mdpi

【 摘 要 】

Disorders of lipid and lipoprotein metabolism and transport are responsible for the development of a large spectrum of pathologies, ranging from cardiovascular diseases, to metabolic syndrome, even to tumour development. Recently, a deeper knowledge of the molecular mechanisms that control our biological clock and circadian rhythms has been achieved. From these studies it has clearly emerged how the molecular clock tightly regulates every aspect of our lives, including our metabolism. This review analyses the organisation and functioning of the circadian clock and its relevance in the regulation of physiological processes. We also describe metabolism and transport of lipids and lipoproteins as an essential aspect for our health, and we will focus on how the circadian clock and lipid metabolism are greatly interconnected. Finally, we discuss how a deeper knowledge of this relationship might be useful to improve the recent spread of metabolic diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.