Ribonucleoprotein Complexes That Control Circadian Clocks

International Journal of Molecular Sciences

Dongni Wang¹  Xiaodi Liang¹  Xianyun Chen¹ 

[1] Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China;

关键词: ribonucleoprotein;    circadian clock;    transcription;    translation;    post-transcription;   

DOI  :  10.3390/ijms14059018

来源: mdpi

【 摘 要 】

Circadian clocks are internal molecular time-keeping mechanisms that enable organisms to adjust their physiology and behavior to the daily surroundings. Misalignment of circadian clocks leads to both physiological and health impairment. Post-transcriptional regulation and translational regulation of circadian clocks have been extensively investigated. In addition, accumulating evidence has shed new light on the involvement of ribonucleoprotein complexes (RNPs) in the post-transcriptional regulation of circadian clocks. Numerous RNA-binding proteins (RBPs) and RNPs have been implicated in the post-transcriptional modification of circadian clock proteins in different model organisms. Herein, we summarize the advances in the current knowledge on the role of RNP complexes in circadian clock regulation.

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland