Alcohol Consumption and Its Influence on the Clinical Picture of Puumala Hantavirus Infection

Viruses

Ilkka Pörsti¹  Jaana Syrjänen¹  Laura Tervo¹  Jukka T. Mustonen¹  Satu Mäkelä¹  Tuula K. Outinen¹  Jenna Mustalahti¹  Onni Niemelä²  Heini Huhtala³ 

[1] Department of Internal Medicine, Tampere University Hospital, 33520 Tampere, Finland;Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland;Faculty of Social Sciences, Tampere University, 33520 Tampere, Finland;

关键词: Puumala hantavirus;    hemorrhagic fever with renal syndrome;    alcohol drinking;    ethanol;    liver enzymes;    pancreatitis;   

DOI  :  10.3390/v14030500

来源: DOAJ

【 摘 要 】

Puumala hantavirus (PUUV) causes hemorrhagic fever with renal syndrome. Characteristic clinical findings include acute kidney injury (AKI), thrombocytopenia, and capillary leakage. Smoking increases the risk of severe AKI, but it is not known whether alcohol consumption predisposes patients to a more severe infection. Liver and pancreatic enzymes, as well as biomarkers of alcohol consumption (gamma-glutamyl transferase, GGT; carbohydrate-deficient transferrin, CDT; GGT-CDT combination; and ethyl glucuronide, EtG), were measured from 66 patients with acute PUUV infection during hospitalization and at the convalescence phase. Alcohol consumption was present in 41% of the study population, 15% showing signs of heavy drinking. Alcohol use did not affect the severity of PUUV induced AKI nor the overall clinical picture of the infection. Liver enzyme levels (GGT or alanine aminotransferase, ALT) were elevated in 64% of the patients, but the levels did not associate with the markers reflecting the severity of the disease. Serum amylase activities at the convalescent stage were higher than those at the acute phase (p < 0.001). No cases with acute pancreatitis were found. In conclusion, our findings indicate that alcohol consumption does not seem to affect the clinical course of an acute PUUV infection.

【 授权许可】

Unknown