Alcohol Consumption and Risk of Glioma: A Meta-Analysis of 19 Observational Studies

Nutrients

Zhen-Yu Qi²  Chuan Shao¹  Chao Yang²  Zhong Wang² 

[1] Department of Neurosurgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China;

关键词: glioma;    alcohol drinking;    ethanol;    meta-analysis;    risk factor;   

DOI  :  10.3390/nu6020504

来源: mdpi

【 摘 要 】

The relationship between risk of glioma and alcohol consumption has been widely studied, but results have been conflicting. We therefore conducted a meta-analysis of observational studies to systematically assess the relationship between alcohol drinking and risk of glioma. Two electronic databases (PubMed and EMBASE) were searched from inception to 8 August 2013 to identify pertinent studies that linked alcohol drinking with glioma risk. We used a random-effects model to calculate the overall relative risk (RR) with corresponding 95% confidence intervals (CIs). Fifteen case-control and four cohort studies were identified for this analysis. The combined RR for total alcohol drinkers versus non-drinkers was 0.96 (95% CI: 0.89–1.04). In the subgroup analysis by geographic area, a significant association was observed in North American studies (RR = 0.78, 95% CI: 0.65–0.93), but not in European or Asian/Australian studies. In the subgroup analysis by study design, a borderline significant association emerged in population-based case-control studies (RR = 0.82, 95% CI: 0.68–0.99), but not in hospital-based case-control studies (RR = 1.00, 95% CI: 0.99–1.01) or cohort group (RR = 1.03, 95% CI: 0.88–1.20). Our results show no material association between alcohol consumption and risk of glioma existed. Further prospective evidences are needed to confirm this association.

【 授权许可】

CC BY   
© 2014 by the authors; licensee MDPI, Basel, Switzerland.