Frontiers in Cell and Developmental Biology | |
Role of Exosomal Non-Coding RNAs in Bone-Related Diseases | |
Xinyan Xie1  Haoye Hu2  Hao He4  Haihong Zhu5  Qiyue Zheng5  Jiaojiao Wang5  Qiong Lu5  Hang Li5  | |
[1] College of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China;Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China;Institute of Clinical Pharmacy, Central South University, Changsha, China; | |
关键词: bone-related diseases; exosomes; non-coding RNAs; osteoporosis; osteoarthritis; | |
DOI : 10.3389/fcell.2021.811666 | |
来源: DOAJ |
【 摘 要 】
Bone-related diseases seriously affect the lives of patients and carry a heavy economic burden on society. Treatment methods cannot meet the diverse clinical needs of affected patients. Exosomes participate in the occurrence and development of many diseases through intercellular communication, including bone-related diseases. Studies have shown that exosomes can take-up and “package” non-coding RNAs and “deliver” them to recipient cells, thereby regulating the function of recipient cells. The exosomal non-coding RNAs secreted by osteoblasts, osteoclasts, chondrocytes, and other cells are involved in the regulation of bone-related diseases by inhibiting osteoclasts, enhancing chondrocyte activity and promoting angiogenesis. Here, we summarize the role and therapeutic potential of exosomal non-coding RNAs in the bone-related diseases osteoporosis, osteoarthritis, and bone-fracture healing, and discuss the clinical application of exosomes in patients with bone-related diseases.
【 授权许可】
Unknown