Role of Exosomal Non-Coding RNAs in Bone-Related Diseases

Frontiers in Cell and Developmental Biology

Xinyan Xie¹  Haoye Hu²  Hao He⁴  Haihong Zhu⁵  Qiyue Zheng⁵  Jiaojiao Wang⁵  Qiong Lu⁵  Hang Li⁵ 

[1] College of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China;Department of Medical Genetics, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China;Institute of Clinical Pharmacy, Central South University, Changsha, China;

关键词: bone-related diseases;    exosomes;    non-coding RNAs;    osteoporosis;    osteoarthritis;   

DOI  :  10.3389/fcell.2021.811666

来源: DOAJ

【 摘 要 】

Bone-related diseases seriously affect the lives of patients and carry a heavy economic burden on society. Treatment methods cannot meet the diverse clinical needs of affected patients. Exosomes participate in the occurrence and development of many diseases through intercellular communication, including bone-related diseases. Studies have shown that exosomes can take-up and “package” non-coding RNAs and “deliver” them to recipient cells, thereby regulating the function of recipient cells. The exosomal non-coding RNAs secreted by osteoblasts, osteoclasts, chondrocytes, and other cells are involved in the regulation of bone-related diseases by inhibiting osteoclasts, enhancing chondrocyte activity and promoting angiogenesis. Here, we summarize the role and therapeutic potential of exosomal non-coding RNAs in the bone-related diseases osteoporosis, osteoarthritis, and bone-fracture healing, and discuss the clinical application of exosomes in patients with bone-related diseases.

【 授权许可】

Unknown