Role of Exosomal Non-coding RNAs in Gastric Cancer: Biological Functions and Potential Clinical Applications

Frontiers in Oncology

Min Rao¹  Fan Li²  Minjie Wan³  Huibo Liu⁴  Manli Zhang⁵  Feng Hu⁵  Jixuan Liu⁶  Yanfang Jiang⁷ 

[1] Transplantation of the Ministry of Education, Genetic Diagnosis Center, The First Hospital of Jilin University, Changchun, China;Department of Anesthesia, The First Hospital of Jilin University, Changchun, China;Department of Central Laboratory, The First Hospital of Jilin University, Changchun, China;Department of Dermatology, The First Hospital of Jilin University, Changchun, China;Department of Gastroenterology, The First Hospital of Jilin University, Changchun, China;Department of Pathology, The First Hospital of Jilin University, Changchun, China;;Key Laboratory of Organ Regeneration &

关键词: non-coding RNAs;    exosomes;    gastric cancer;    molecular mechanism;    biomarker;    cancer therapy;   

DOI  :  10.3389/fonc.2021.700168

来源: DOAJ

【 摘 要 】

Gastric cancer (GC) is one of the most common fatal cancers worldwide. The communication between GC and other cells in the GC microenvironment directly affects GC progression. Recently, exosomes have been revealed as new players in intercellular communication. They play an important role in human health and diseases, including cancer, owing to their ability to carry various bioactive molecules, including non-coding RNAs (ncRNAs). NcRNAs, including micro RNAs, long non-coding RNAs, and circular RNAs, play a significant role in various pathophysiological processes, especially cancer. Increasing evidence has shown that exosomal ncRNAs are involved in the regulation of tumor proliferation, invasion, metastasis, angiogenesis, immune regulation, and treatment resistance in GC. In addition, exosomal ncRNAs have promising potential as diagnostic and prognostic markers for GC. Considering the biocompatibility of exosomes, they can also be used as biological carriers for targeted therapy. This review summarizes the current research progress on exosomal ncRNAs in gastric cancer, focusing on their biological role in GC and their potential as new biomarkers for GC and therapeutics. Our review provides insight into the mechanisms involved in GC progression, which may provide a new point cut for the discovery of new diagnostic markers and therapeutic strategies.

【 授权许可】

Unknown