Genetic and Environmental Factors Contributing to Parkinson's Disease: A Case-Control Study in the Cypriot Population

Frontiers in Neurology

Alexandros Heraclides¹  Christiana A. Demetriou¹  Andreas Hadjisavvas²  Maria A. Loizidou²  Panayiotis Loukaides³  Eleni Leonidou⁴  Yiolanda P. Christou⁴  Elena Yiasoumi⁵  Andrea Georgiou⁶  Savvas S. Papacostas⁶  Marios Pantziaris⁶  Eleni Zamba-Papanicolaou⁶  Kleopas A. Kleopa⁶ 

[1] Department of Primary Care and Population Health, University of Nicosia Medical School, Nicosia, Cyprus;Electron Microscopy and Molecular Pathology Department, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus;Limassol General Hospital, Limassol, Cyprus;Neurology Clinics, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus;Private Neurology Clinic, Larnaca, Cyprus;The Cyprus School of Molecular Medicine, The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus;

关键词: Parkinson's disease;    environmental factors;    genetic variants;    Cypriot population;    observational study;    case-control study;   

DOI  :  10.3389/fneur.2019.01047

来源: DOAJ

【 摘 要 】

Introduction: Parkinson's disease (PD) is a neurodegenerative disorder affecting a substantial proportion of the elderly Cypriot population. The objective of this study was to evaluate PD risk variants that have been identified previously in Genome Wide Association Studies (GWAS) and to find environmental factors that are predictors for PD onset in the Cypriot population.Methods: A case-control study was conducted with a total of 235 PD patients and 464 healthy controls of Greek-Cypriot ethnicity. Demographic and lifestyle characteristics, exposure to PD risk factors and clinical data were collected. Moreover, 13 previously GWAS-identified PD risk variants were genotyped. Univariate and multivariate regression analyses examined the association between a number of environmental and genetic factors and PD.Results: Multivariable regression analysis revealed that exposure to both pesticides and other toxic substances (P = 0.03), severe head injury accompanied with fainting (P = 0.001), nuts consumption (P = 0.004), red meat consumption (P = 0.02), and soft drinks consumption (P = 0.008) were increasing the risk for PD, whereas cumulative smoking (P = 0.02), and fish consumption (P = 0.02) were decreasing the risk for PD. Five out of the 13 tested SNPs (rs12185268, rs6599389, rs356220, rs13312, and rs17649553) were confirmed to be nominally significantly associated (P < 0.05) with PD risk in the Cypriot population.Conclusions: Collectively, this case-control study has shed some light on the nature of PD epidemiology in Cyprus, by demonstrating a number of genetic and environmental determinants of PD in the Cypriot population.

【 授权许可】

Unknown