A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil

Frontiers in Medicine

Laura Fernandes Gonçalves¹  Kelly Grace Magalhães¹  Vicente de Paulo Martins¹  Tatiana Amabile de Campos¹  Georgios Joannis Pappas Júnior¹  Eliana Guedes Stehling²  Guilherme Bartolomeu Gonçalves²  João Pedro Rueda Furlan²  Gisele Peirano³  Johann D. D. Pitout³  André Pitondo-Silva⁴ 

[1] Department of Cell Biology, Institute of Biological Sciences, University of Brasilia, Brasília, Brazil;Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil;Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada;School of Dentistry, University of Ribeirão Preto, Ribeirão Preto, Brazil;

关键词: Klebsiella pneumoniae;    hypermucousviscous;    KPC-2;    XDR;    ST11;    virulence;   

DOI  :  10.3389/fmed.2018.00265

来源: DOAJ

【 摘 要 】

We report a fatal bacteremia caused by Klebsiella pneumoniae in a 60–70-year-old patient from Brazil. The genomic analysis of three isolates (from blood culture, nasal and anal swabs) showed that the bacteremia was caused by a KPC-2 producing extensively drug-resistant K64-ST11 hypermucousviscous K. pneumoniae (hmKP) harboring several virulence and antimicrobial resistance genes. Although the isolates did not present virulence markers associated with hypervirulent K. pneumoniae (hvKP), they showed invasion and toxicity to epithelial Hep-2 cells; resistance to cell microbicidal mechanisms; and blood and human serum survival, evidencing their pathogenic potential. This study highlights the risk of infection caused by hmKp strains not characterized as hvKP as well as the clinical implications and difficulty of treatment, especially in elderly or immunocompromised patients.

【 授权许可】

Unknown