Immunogenicity and protective efficacy of BBV152, whole virion inactivated SARS- CoV-2 vaccine candidates in the Syrian hamster model

iScience

Anita Shete-Aich¹  Manoj Kadam²  Sai D. Prasad²  Sharda Sharma²  Gajanan Sapkal²  Samiran Panda²  Dimpal Nyayanit³  Balram Bhargava⁴  Vellimedu Kannappa Srinivas⁴  Chandrashekhar Mote⁵  Krishna M. Ella⁵  Pragya D. Yadav⁵  Krishna Mohan Vadrevu⁵  Triparna Majumdar⁵  Nivedita Gupta⁵  Prasad Sarkale⁵  Raches Ella⁵  Deepak Patil⁵  Abhimanyu Kumar⁵  Savita Patil⁵  Gururaj Deshpande⁵  Sreelekshmy Mohandas⁵  Priya Abraham⁵  Rajlaxmi Jain⁵ 

[1] Corresponding author;Bharat Biotech International Limited, Genome Valley, Hyderabad, Telangana 500 078, India;Department of Veterinary Pathology, Krantisinh Nana Patil College of Veterinary Science, Shirwal, Maharashtra 412801, India;Indian Council of Medical Research,V. Ramalingaswami Bhawan, P.O. Box No. 4911, Ansari Nagar, New Delhi 110029, India;Indian Council of Medical Research-National Institute of Virology, Sus Road, Pashan, Pune, Maharashtra 411021, India;

关键词: Biological Sciences;    Immunity;    Immunology;    Viral Microbiology;    Virology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: The availability of a safe and effective vaccine would be the eventual measure to deal with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) threat. Here, we have assessed the immunogenicity and protective efficacy of inactivated SARS-CoV-2 vaccine candidates BBV152A, BBV152B, and BBV152C in Syrian hamsters. Three dose vaccination regimes with vaccine candidates induced significant titers of SARS-CoV-2-specific IgG and neutralizing antibodies. BBV152A and BBV152B vaccine candidates remarkably generated a quick and robust immune response. Post-SARS-CoV-2 infection, vaccinated hamsters did not show any histopathological changes in the lungs. The protection of the hamster was evident by the rapid clearance of the virus from lower respiratory tract, reduced virus load in upper respiratory tract, absence of lung pathology, and robust humoral immune response. These findings confirm the immunogenic potential of the vaccine candidates and further protection of hamsters challenged with SARS-CoV-2. Of the three candidates, BBV152A showed the better response.

【 授权许可】

Unknown