Maternal Programming of Social Dominance via Milk Cytokines

iScience

Emily Pickup¹  Steven Gross¹  Faten Taki¹  Paul Bergin¹  Luendreo Barboza¹  Judit Gal Toth¹  Miklos Toth¹  Katherine Lopez¹  Qiuying Chen¹  Marcel R.M. van den Brink²  Kimon V. Argyropoulos²  Melissa D. Docampo²  Michele Alves-Bezerra³  David E. Cohen³  Bojana Zupan⁴  Nicholas Fancher⁴  Abbi Hiller⁴ 

[1] Department of Pharmacology, Weill Cornell Medical College, 1300 York Avenue, New York, NY 10065, USA;Departments of Medicine and Immunology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA;Division of Gastroenterology and Hepatology, Weill Department of Medicine, Weill Cornell Medical College, 1305 York Avenue, New York, NY 10021, USA;Psychological Science Department, Vassar College, Poughkeepsie 124 Raymond Avenue, New York, NY 12604, USA;

关键词: Biological Sciences;    Behavioral Neuroscience;    Immunology;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Regular physical activity improves physical and mental health. Here we found that the effect of physical activity extends to the next generation. Voluntary wheel running of dams, from postpartum day 2 to weaning, increased the social dominance and reproductive success, but not the physical/metabolic health, of their otherwise sedentary offspring. The individual's own physical activity did not improve dominance status. Maternal exercise did not disrupt maternal care or the maternal and offspring microbiota. Rather, the development of dominance behavior in the offspring of running mothers could be explained by the reduction of LIF, CXCL1, and CXCL2 cytokines in breast milk. These data reveal a cytokine-mediated lactocrine pathway that responds to the mother's postpartum physical activity and programs offspring social dominance. As dominance behaviors are highly relevant to the individual's survival and reproduction, lactocrine programming could be an evolutionary mechanism by which a mother promotes the social rank of her offspring.

【 授权许可】

Unknown