Reversal of Multidrug Resistance in Cancer by Multi-Functional Flavonoids

Frontiers in Oncology

Ren-Wang Jiang¹  Qun Shen²  Qingmei Ye²  Kai Liu²  Qingyue Li²  Fangxuan Han²  Jinghui Hao³ 

[1] Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education, Jinan University, Guangzhou, China;Hainan General Hospital, Haikou, China;Jiaozuo Second People's Hospital, Jiaozuo, China;

关键词: multidrug resistance;    natural products;    flavonoids;    overcome;    cancer;    drug discovery;   

DOI  :  10.3389/fonc.2019.00487

来源: DOAJ

【 摘 要 】

Multidrug resistance (MDR) resulting from different defensive mechanisms in cancer is one of the major obstacles of clinical treatment. To circumvent MDR many reversal agents have been developed, but most of them fail in clinical trials due to severely adverse effects. Recently, certain natural products have been reported to overcome MDR, including flavonoids which are abundant in plants, foods, and herbs. The structure of flavonoids can be abbreviated as C6-C3-C6 (C for carbon), and further categorized into flavonoids, iso-flavonoids and neo-flavonoids, according to their structural backbones. Flavonoids possess multiple bioactivities, and a growing body of research has indicated that both flavonoids and iso-flavonoids can either kill or re-sensitize conventional chemotherapeutics to resistant cancer cells. Here, we summarize the research and discuss the underlying mechanisms, concluding that these flavonoids do not function as specific regulators of target proteins, but rather as multi-functional agents that negatively regulate the key factors contributing to MDR.

【 授权许可】

Unknown