IFN-Aging: Coupling Aging With Interferon Response

Frontiers in Aging

关键词: aging;    interferon;    senescence;    inflammaging;    transposable elements;    laminopathy;   

DOI  :  10.3389/fragi.2022.870489

来源: DOAJ

【 摘 要 】

Chronic inflammation affects many diseases and conditions, including aging. Interferons are a part of the immune defense against viral infections. Paradoxically, various aging tissues and organs from mammalian hosts perpetually accumulate changes brought by interferon pathway activation. Herein, we connote the mechanisms behind this phenomenon and discuss its implications in age-related pathology.

【 授权许可】

Unknown