Modern Concepts in Cardiovascular Disease: Inflamm-Aging

Frontiers in Cell and Developmental Biology

Yustina M. Puspitasari¹  Lena Schwarz¹  Caroline Karch¹  Giovanni G. Camici³  Luca Liberale⁵  Stefano Ministrini⁶ 

[1] Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland;Department of Cardiology, University Heart Center, University Hospital Zurich, Zurich, Switzerland;Department of Research and Education, University Hospital Zurich, Zurich, Switzerland;First Clinic of Internal Medicine, Department of Internal Medicine, University of Genoa, Genoa, Italy;IRCCS Ospedale Policlinico San Martino Genoa—Italian Cardiovascular Network, Genoa, Italy;Internal Medicine, Angiology and Atherosclerosis, Department of Medicine and Surgery, University of Perugia, Perugia, Italy;

关键词: inflammaging;    cardiovascular disease;    aging;    inflammation;    senescence;   

DOI  :  10.3389/fcell.2022.882211

来源: DOAJ

【 摘 要 】

The improvements in healthcare services and quality of life result in a longer life expectancy and a higher number of aged individuals, who are inevitably affected by age-associated cardiovascular (CV) diseases. This challenging demographic shift calls for a greater effort to unravel the molecular mechanisms underlying age-related CV diseases to identify new therapeutic targets to cope with the ongoing aging "pandemic". Essential for protection against external pathogens and intrinsic degenerative processes, the inflammatory response becomes dysregulated with aging, leading to a persistent state of low-grade inflammation known as inflamm-aging. Of interest, inflammation has been recently recognized as a key factor in the pathogenesis of CV diseases, suggesting inflamm-aging as a possible driver of age-related CV afflictions and a plausible therapeutic target in this context. This review discusses the molecular pathways underlying inflamm-aging and their involvement in CV disease. Moreover, the potential of several anti-inflammatory approaches in this context is also reviewed.

【 授权许可】

Unknown