Atherosclerosis Imaging with 18F-Sodium Fluoride PET

Diagnostics

Michael Sturek¹  KasperKarmark Iversen²  Oke Gerke³  Caius Constantinescu³  PoulF. Høilund-Carlsen³  Reza Piri³  ThomasJ. Werner⁴  Abass Alavi⁴ 

[1] Department of Anatomy, Cell Biology, Physiology, Indiana University School of Medicine, Indianapolis, IN 46202, USA;Department of Cardiology, Herlev Gentofte Hospital, 2900 Herlev, Denmark;Department of Nuclear Medicine, Odense University Hospital, 5000 Odense, Denmark;Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA;

关键词: atherosclerosis;    PET;    ¹⁸F-sodium fluoride;    NaF;    calcification;    quantification;   

DOI  :  10.3390/diagnostics10100852

来源: DOAJ

【 摘 要 】

The evidence on atherosclerosis imaging with ¹⁸F-sodium-fluoride (NaF) positron emission tomography (PET) is hotly debated because of the different patient characteristics, methodology, vascular beds, etc. in reported studies. This review is a continuation of a previous review on this topic, which covered the period 2010–2018. The purpose was to examine whether some of the most important questions that the previous review had left open had been elucidated by the most recent literature. Using principles of a systematic review, we ended analyzing 25 articles dealing with the carotids, coronary arteries, aorta, femoral, intracranial, renal, and penile arteries. The knowledge thus far can be summarized as follows: by targeting active arterial microcalcification, NaF uptake is considered a marker of early stage atherosclerosis, is age-dependent, and consistently associated with cardiovascular risk. Longitudinal studies on NaF uptake, conducted in the abdominal aorta only, showed unchanged uptake in postmenopausal women for nearly four years and varying uptake in prostate cancer patients over 1.5 years, despite constant or increasing calcium volume detected by computed tomography (CT). Thus, uncertainty remains about the transition from active arterial wall calcification marked by increased NaF uptake to less active or consolidated calcification detected by CT. The question of whether early-phase atherosclerosis and calcification can be modified remains also unanswered due to lack of intervention studies.

【 授权许可】

Unknown