Feasibility of 18F-Sodium Fluoride PET/CT for Imaging of Atherosclerotic Plaque

Journal of Nuclear Medicine

Thorsten Derlin¹  Ulrich Richter¹  Peter Bannas¹  Ralph Buchert¹  Janos Mester¹  Philipp Begemann¹  Susanne Klutmann¹ 

关键词: ¹⁸F-sodium fluoride;    plaque;    atherosclerosis;    calcification;    PET;    PET/CT;   

DOI  :  10.2967/jnumed.110.076471

学科分类：医学（综合）

来源: Society of Nuclear Medicine

【 摘 要 】

The aim of this study was to examine the prevalence, distribution, and topographic relationship of vascular 18F-sodium fluoride uptake and arterial calcification in major arteries. Methods: Image data obtained from 75 patients undergoing whole-body 18F-sodium fluoride PET/CT were evaluated retrospectively. Arterial radiotracer uptake and calcification were analyzed qualitatively and semiquantitatively. Results: 18F-sodium fluoride uptake was observed at 254 sites in 57 (76%) of the 75 study patients, and calcification was observed at 1,930 sites in 63 (84%) of the patients. Colocalization of radiotracer accumulation and calcification could be observed in 223 areas of uptake (88%). However, only 12% of all arterial calcification sites showed increased radiotracer uptake. Conclusion: Our data indicate the feasibility of 18F-sodium fluoride PET/CT for the imaging of mineral deposition in arterial wall alterations. 18F-sodium fluoride PET/CT may provide relevant information about the morphologic and functional properties of calcified plaque.

【 授权许可】

Unknown