Interaction between Fibroblasts and Immune Cells Following DNA Damage Induced by Ionizing Radiation

International Journal of Molecular Sciences

Valentyn Oksenych¹  Kalaiyarasi Ragunathan¹  NikkiLyn Esnardo Upfold¹ 

[1] Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7028 Trondheim, Norway;

关键词: DNA repair;    lymphocyte;    immune system;    DNA breaks;    cancer-associated fibroblasts;   

DOI  :  10.3390/ijms21228635

来源: DOAJ

【 摘 要 】

Cancer-associated fibroblasts (CAF) form the basis of tumor microenvironment and possess immunomodulatory functions by interacting with other cells surrounding tumor, including T lymphocytes, macrophages, dendritic cells and natural killer cells. Ionizing radiation is a broadly-used method in radiotherapy to target tumors. In mammalian cells, ionizing radiation induces various types of DNA damages and DNA damage response. Being unspecific, radiotherapy affects all the cells in tumor microenvironment, including the tumor itself, CAFs and immune cells. CAFs are extremely radio-resistant and do not initiate apoptosis even at high doses of radiation. However, following radiation, CAFs become senescent and produce a distinct combination of immunoregulatory molecules. Radiosensitivity of immune cells varies depending on the cell type due to inefficient DNA repair in, for example, monocytes and granulocytes. In this minireview, we are summarizing recent findings on the interaction between CAF, ionizing radiation and immune cells in the tumor microenvironment.

【 授权许可】

Unknown