期刊论文详细信息
Molecular Autism
Abnormal coherence and sleep composition in children with Angelman syndrome: a retrospective EEG study
Benjamin D. Philpot1  Hanna den Bakker1  Michael S. Sidorov1  Catherine J. Chu2  Zheng Fan3  David J. Lee4  Lynne M. Bird5 
[1] Department of Cell Biology and Physiology, University of North Carolina;Department of Neurology, Massachusetts General Hospital;Department of Neurology, University of North Carolina;Department of Neurosciences, University of California;Department of Pediatrics, University of California;
关键词: Angelman syndrome;    UBE3A;    EEG;    Coherence;    Spindles;    Biomarker;   
DOI  :  10.1186/s13229-018-0214-8
来源: DOAJ
【 摘 要 】

Abstract Background Angelman syndrome (AS) is a neurodevelopmental disorder characterized by intellectual disability, speech and motor impairments, epilepsy, abnormal sleep, and phenotypic overlap with autism. Individuals with AS display characteristic EEG patterns including high-amplitude rhythmic delta waves. Here, we sought to quantitatively explore EEG architecture in AS beyond known spectral power phenotypes. We were motivated by studies of functional connectivity and sleep spindles in autism to study these EEG readouts in children with AS. Methods We analyzed retrospective wake and sleep EEGs from children with AS (age 4–11) and age-matched neurotypical controls. We assessed long-range and short-range functional connectivity by measuring coherence across multiple frequencies during wake and sleep. We quantified sleep spindles using automated and manual approaches. Results During wakefulness, children with AS showed enhanced long-range EEG coherence across a wide range of frequencies. During sleep, children with AS showed increased long-range EEG coherence specifically in the gamma band. EEGs from children with AS contained fewer sleep spindles, and these spindles were shorter in duration than their neurotypical counterparts. Conclusions We demonstrate two quantitative readouts of dysregulated sleep composition in children with AS—gamma coherence and spindles—and describe how functional connectivity patterns may be disrupted during wakefulness. Quantitative EEG phenotypes have potential as biomarkers and readouts of target engagement for future clinical trials and provide clues into how neural circuits are dysregulated in children with AS.

【 授权许可】

Unknown   

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