The Role of Mast Cells in Tuberculosis: Orchestrating Innate Immune Crosstalk?

Frontiers in Immunology

Rogelio Hernández-Pando¹  Silvia Bulfone-Paus²  Karen M. Garcia-Rodriguez³  Maria T. Alonso-Rasgado³  Anu Goenka⁴ 

[1] Departamento de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición “Salvador Zubiran”, Mexico City, Mexico;Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom;Faculty of Science and Engineering, School of Materials, University of Manchester, Manchester, United Kingdom;Manchester Collaborative Centre for Inflammation Research, Faculty of Biology, Medicine and Health, School of Biological Sciences, Manchester, United Kingdom;

关键词: Mycobacterium tuberculosis;    mast cells;    degranulation;    extracellular traps;    granuloma;    infection;   

DOI  :  10.3389/fimmu.2017.01290

来源: DOAJ

【 摘 要 】

Tuberculosis causes more annual deaths globally than any other infectious disease. However, progress in developing novel vaccines, diagnostics, and therapies has been hampered by an incomplete understanding of the immune response to Mycobacterium tuberculosis (Mtb). While the role of many immune cells has been extensively explored, mast cells (MCs) have been relatively ignored. MCs are tissue resident cells involved in defense against bacterial infections playing an important role mediating immune cell crosstalk. This review discusses specific interactions between MCs and Mtb, their contribution to both immunity and disease pathogenesis, and explores their role in orchestrating other immune cells against infections.

【 授权许可】

Unknown