The beneficial pharmacological effects and potential mechanisms of picroside II: Evidence of its benefits from in vitro and in vivo

Biomedicine & Pharmacotherapy

Feifan Lai¹  Shangying Ma¹  Xueyi Wang¹  Chenghua Lou² 

[1] College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, 310053, China;Corresponding author at: School of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou, 310053, China.;

关键词: Picroside II;    Anti-apoptosis;    Anti-oxidant;    Ischemia/reperfusion injury;    Anti-inflammation;    Pharmacokinetics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Picrorhiza kurroa, the dried rhizome of Picrorhiza kurroa Royle ex Benth, is a famous Chinese herb that has been traditionally used in China. Picroside II (PII), a glycoside derivative, is the main bioactive constituent of Picrorhiza kurroa. In the past several decades, bioactive components from Picrorhiza kurroa have attracted the attention of researchers due to their promising therapeutic effects. A large number of studies have demonstrated the therapeutic potential of PII for the prevention and treatment of some diseases, such as organic ischemia/reperfusion (I/R) injury, liver damage, inflammation, cancer metastasis and angiogenesis. In the present paper, we aimed to provide an overview of the pharmacology of PII, focusing on its anti-oxidant, anti-inflammatory and anti-apoptotic activities. Meanwhile, the plant tissue distribution and pharmacokinetic properties were also described. Due to its beneficial pharmacological effects in I/R injury, PII may serve as a promising therapeutic agent for organic I/R injury prevention.

【 授权许可】

Unknown