Diacerein: Recent insight into pharmacological activities and molecular pathways

Biomedicine & Pharmacotherapy

Yu Zhang¹  Muhammad Shoaib¹  Kamal Hezam²  Bassam Saif³  Ruhan Jia⁴  Emad Shamsan⁴  Fadhl Al-shaebi⁴  Wei Zhang⁵  Ying Han⁵  Mohammed Gamah⁶  Maged Almezgagi⁷  Abdul Baset Abbas⁷ 

[1] Department of Immunology, Medical College of Qinghai University, Qinghai Xining 810001, China;Department of Medical Microbiology, Faculty of Sciences, Ibb University, Ibb City 70270, Yemen;Department of Immunology, Hebei Medical University, Shijiazhuang, Hebei 050017, China;Department of Immunology, Medical College of Qinghai University, Qinghai Xining 810001, China;Department of Medical Microbiology, Faculty of Sciences, Ibb University, Ibb City 70270, Yemen;Nankai University School of Medicine, Tianjin 300071, China;The Key Laboratory of High-Altitude Medical Application of Qinghai Province, Qinghai Xining 810001, China;

关键词: Diacerein;    Anti-inflammatory;    Anti-oxidant;    Anti-apoptosis;    Cytokines;   

DOI  :  

来源: DOAJ

【 摘 要 】

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) and the active metabolite is rhein. It is a non-steroidal anti-inflammatory drug with unique pharmacological properties as anti-oxidant and anti-apoptosis. Diacerein has recently shown to have a potential role by mediating anti-inflammatory as well as anti-oxidant and anti-apoptosis in kidney injury, diabetes mullites, and a beneficial effect on pain relief. It may have a therapeutic role in cancer, ulcerative colitis, testicular injury and cervical hyperkeratosis. Furthermore, diacerein has a valuable addition in combination therapy as a synergetic agent. This review, the first of its kind, highlights the proposed roles of diacerein in osteoarthritis and discusses recent results supporting its emerging roles with a particular focus on how these new insights may facilitate the rational development of diacerein for targeted therapies in the future.

【 授权许可】

Unknown