Emergence of high drug resistant bacterial isolates from patients with health care associated infections at Jimma University medical center: a cross sectional study

Antimicrobial Resistance and Infection Control

Henok Assefa¹  Netsanet Fentahun²  Esayas Kebede Gudina³  Yesuf Ahmed⁴  Sisay Bekele⁵  Melkamu Berhane⁶  Yonas Yilma⁷  Andreas Wieser⁸  Lule Teshager⁹  Solomon Ali⁹  Mulatu Gashaw⁹  Gebre Kibru⁹ 

[1] Department of Epidemiology and Statistics, Jimma University;Department of Health Education and Behavioral Health, Jimma University;Department of Internal Medicine, Jimma University;Department of Obstetrics and Gynecology, Jimma University;Department of Ophthalmology, Jimma University;Department of Pediatrics and Child Health, Jimma University;Department of Surgery, Jimma University;Head of the parasitology laboratory and deputy head of the molecular diagnostics laboratory at the Max von Pettenkofer-Institute, Ludwigs-Maximilians-University (LMU);School of Medical Laboratory Science, Jimma University;

关键词: Antimicrobial agents;    Drug resistant isolates;    Multidrug resistance;    Extensively resistance;    Pandrug resistance;    Carbapenem resistance;   

DOI  :  10.1186/s13756-018-0431-0

来源: DOAJ

【 摘 要 】

Abstract Background The rates of resistant microorganisms which complicate the management of healthcare associated infections (HAIs) are increasing worldwide and getting more serious in developing countries. The objective of this study was to describe microbiological features and resistance profiles of bacterial pathogens of HAIs in Jimma University Medical Center (JUMC) in Ethiopia. Methods Institution based cross sectional study was carried out on hospitalized patients from May to September, 2016 in JUMC. Different clinical specimens were collected from patients who were suspected to hospital acquired infections. The specimens were processed to identify bacterial etiologies following standard microbiological methods. Antibacterial susceptibility was determined in vitro by Kirby-Bauer disk diffusion method following Clinical and Laboratory Standards Institute guidelines. Results Overall, 126 bacterial etiologies were isolated from 118 patients who had HAIs. Of these, 100 (79.4%) were gram negative and the remaining were gram positive. The most common isolates were Escherichia coli 31(24.6%), Klebsiella species 30(23.8%) and Staphylococcus aureus 26 (20.6%). Of 126 bacterial isolates, 38 (30.2%), 52 (41.3%), and 24 (19%) were multidrug-resistant (MDR, resistant to at least one agent in three or more antimicrobial categories), extensively drug resistant (XDR, resistant to at least one agent in all but two or fewer antimicrobial categories (i.e. bacterial isolates remain susceptible to only one or two categories), pan-drug resistant (PDR, resistant to all antibiotic classes) respectively. More than half of isolated gram-negative rods (51%) were positive for extended spectrum beta-lactamase (ESBL) and/or AmpC; and 25% of gram negative isolates were also resistant to carbapenem antibiotics. Conclusions The pattern of drug resistant bacteria in patients with healthcare associated infection at JUMC is alarming. This calls for coordinated efforts from all stakeholders to prevent HAIs and drug resistance in the study setting.

【 授权许可】

Unknown