Continuous cold exposure induces an anti-inflammatory response in mesenteric adipose tissue associated with catecholamine production and thermogenin expression in rats

Endocrine Regulations

Kvetnansky R.¹  Vargovic P.²  Manz G.³ 

[1] Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia;Institute of Experimental Endocrinology, Biomedical Research Center, Slovak Academy of Sciences, Dubravska cesta 9, 845 05 Bratislava 4, Slovakia, phone: [phone];LDN Labor Diagnostica Nord, D-48531, Nordhorn, Germany;

关键词: adipose tissue;    catecholamines;    cold exposure;    thermogenesis;    inflammatory mediators;   

DOI  :  10.1515/enr-2016-0015

来源: DOAJ

【 摘 要 】

Objective. Continuous exposure to cold leads to an activation of adaptive thermogenesis in the brown adipose tissue and induction of brown/beige cell phenotype in the white adipose tissue. Thermogenic response is associated with alternatively activated macrophages producing catecholamines, which subsequently activate the uncoupling protein 1 (UCP-1). The aim of this work was to elucidate the effect of cold exposure on catecholamine and immune responses associated with adipocyte browning in the mesenteric adipose tissue (mWAT) of rat.

【 授权许可】

Unknown