The effect of hypoxia inducible factors on brown adipose tissue thermogenesis

HIF1α;HIF2α;brown adipose tissue;thermogenesis;UCP1;570

자연과학대학 생명과학부 ;

University:서울대학교 대학원

关键词: HIF1α;    HIF2α;    brown adipose tissue;    thermogenesis;    UCP1;    570;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/142443/1/000000150558.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

Systemic energy imbalance between energy intake and expenditure lies at the center of obesity pandemic. Brown adipocyte plays an important role in increasing energy expenditure by generating heat. Hypoxia-inducible factor (HIF) regulates the expression of glucose transporter 1 and several glycolytic enzymes, however its role in brown adipose tissues has not been elucidated, yet. There are two major isoforms of HIF in adipocytes, HIF1α and HIF2α. Here, I studied the mechanism of how HIF1α regulates cold-induced thermogenesis in brown adipocytes. HIF1α expression was increased in brown adipose tissue after cold exposure. Moreover, β adrenergic receptor agonist treatment increased HIF1α expression in brown adipocytes in vitro. HIF1α knockdown decreased isoproterenol- induced UCP1 expression. On the other hand, I found that HIF2α is involved in brown pre-adipocyte differentiation. These results suggest that HIF1α and HIF2α can modulate adaptive thermogenesis in brown adipose tissue.