Gene variants in the FTO gene are associated with adiponectin and TNF-alpha levels in gestational diabetes mellitus

Diabetology & Metabolic Syndrome

Arturo Zarate¹  Lourdes Basurto¹  Jorge Valencia¹  Renata Saucedo¹  Marcelino Hernandez¹  Claudia Gutierrez¹  Edgardo Puello²  Gloria Vega³  Guadalupe Rico³ 

[1] Endocrine Research Unit, National Medical Center, IMSS;Hospital of Gynecology and Obstetrics, Medical Center La Raza, IMSS;Unit of Experimental Medicine, UNAM;

关键词: Adipokines;    FTO;    Gestational diabetes;    Obesity;    Single nucleotide polymorphism;   

DOI  :  10.1186/s13098-017-0234-0

来源: DOAJ

【 摘 要 】

Abstract Background Obesity may have a role in the development of gestational diabetes mellitus (GDM). Single-nucleotide-polymorphisms (SNPs) of the FTO (fat mass and obesity associated) gene have been associated with obesity. The aim of this study was to investigate SNPs rs8050136, rs9939609, and rs1421085 of the FTO gene in women with GDM and their associations with maternal pre-pregnancy weight and body mass index, gestational weight gain and mediators of insulin resistance in GDM like leptin, adiponectin, ghrelin and tumor necrosis factor-alpha (TNF-alpha), compared with healthy pregnant controls. Methods 80 women with GDM and 80 women with normal pregnancy were considered for the present study. Genotyping of selected SNPs in all study subjects was done using the Taq-Man assay and the adipokines and ghrelin were measured by immunoassays. Chi square test, odds ratios (OR) and their respective 95% confidence intervals were used to measure the strength of association between FTO SNPs and GDM. Results There was no association among FTO SNPs and GDM. Interestingly, in GDM group, women carrying the risk alleles of the three SNPs had increased TNF-alpha, and decreased adiponectin levels; these associations remained significant after adjusting for pre-gestational body weight and age. Moreover, the risk allele of rs1421085 was also associated with increased weight gain during pregnancy. Conclusions The FTP SNPs rs8050136, rs9939609, and rs1421085 are not a major genetic regulator in the etiology of GDM in the studied ethnic group. However, these SNPs were associated with adiponectin and TNF-alpha concentrations in GDM subjects.

【 授权许可】

Unknown