Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

BMC Research Notes

Athraa Alaulddin Al-Jawadi¹  I Made Artika²  Mulianah Daya³  Safarina G. Malik⁴  Clarissa A. Febinia⁴  Sukma Oktavianthi⁴  Lidwina Priliani⁴ 

[1] Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, 16680, Bogor, West Java, Indonesia;Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University, Kampus IPB Dramaga, Jl. Raya Dramaga, 16680, Bogor, West Java, Indonesia;Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, 10430, Jakarta, Indonesia;Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia;Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency, Jl. Diponegoro No. 69, 10430, Jakarta, Indonesia;

关键词: FTO;    rs1421085;    Fatty acid;    Fat intake;    Obesity;    Indonesia;   

DOI  :  10.1186/s13104-021-05823-1

来源: Springer

【 摘 要 】

ObjectiveRecent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models.ResultsOnly individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.

【 授权许可】

CC BY