Association of FTO rs1421085 single nucleotide polymorphism with fat and fatty acid intake in Indonesian adults

BMC Research Notes

Athraa Alaulddin Al-Jawadi¹  I Made Artika¹  Mulianah Daya²  Sukma Oktavianthi³  Lidwina Priliani³  Clarissa A. Febinia³  Safarina G. Malik³ 

[1] Department of Biochemistry, Faculty of Mathematics and Natural Sciences, Bogor Agricultural University;Department of Nutrition, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo National General Hospital;Eijkman Institute for Molecular Biology, Ministry of Research and Technology/National Research and Innovation Agency;

关键词: FTO;    rs1421085;    Fatty acid;    Fat intake;    Obesity;    Indonesia;   

DOI  :  10.1186/s13104-021-05823-1

来源: DOAJ

【 摘 要 】

Abstract Objective Recent studies showed that genetic polymorphisms in the fat mass and obesity-associated gene (FTO) were associated with obesity and dietary intake. In this study of 71 adults in Jakarta, Indonesia, we investigated FTO rs1421085 association with body mass index (BMI), macronutrient intake, and fatty acid intake. The association was evaluated using linear regression analyses assuming co-dominant, dominant, recessive, over-dominant, and additive genetic models. Results Only individuals with the CC genotype had a considerably higher BMI (p < 0.001), which indicates a recessive genetic trait, but the incidence for this genotype is low (68 TT + TC vs. 3 CC). Individuals with the minor C allele had an estimated increase of fat intake by 3.45–4.06% across various genetic models (dominant: p < 0.010, over-dominant: p < 0.030, additive: p < 0.010). Subjects with TC/CC genotypes had increased dietary monounsaturated fatty acid (MUFA; 1.14%, p = 0.046) and saturated fatty acid (SAFA; 2.06%, p = 0.023) intakes, compared to those with the TT genotype. In conclusion, our study provided evidence for the association between FTO rs1421085 risk allele with higher BMI and individual preferences for consuming more fat, MUFA, and SAFA. This study highlights the important role of FTO gene in food preference, and its influence on body weight.

【 授权许可】

Unknown