A 2-month-old boy with hemolytic anemia and reticulocytopenia following intravenous immunoglobulin therapy for Kawasaki disease: a case report and literature review

Korean Journal of Pediatrics

Myung Suh Kang¹  Soo Hyun Kim²  Yeon Kyung Cho²  Dong Hyun Cha²  Na Yeon Kim³  Joon Hwan Kim³  Jin Suk Park³  Ki Eun Kim⁴  Kyung Ah Lim⁴  Youn Ho Sheen⁴ 

[1] Department of Laboratory Medicine, CHA Bundang Medical Center, CHA University, Seongnam, Korea.;Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.;Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea.;Department of Pediatrics, CHA Gangnam Medical Center, CHA University, Seoul, Korea.;

关键词: Anemia;    Hemolysis;    Kawasaki disease;    Reticulocytes;   

DOI  :  10.3345/kjp.2016.59.11.S60

来源: DOAJ

【 摘 要 】

Herein, we report a rare case of hemolytic anemia with reticulocytopenia following intravenous immunoglobulin therapy in a young infant treated for Kawasaki disease. A 2-month-old boy presented with fever lasting 3 days, conjunctival injection, strawberry tongue, erythematous edema of the hands, and macular rash, symptoms and signs suggestive of incomplete Kawasaki disease. His fever resolved 8 days after treatment with aspirin and high dose infusion of intravenous immunoglobulin. The hemoglobin and hematocrit decreased from 9.7 g/dL and 27.1% to 7.4 g/dL and 21.3%, respectively. The patient had normocytic hypochromic anemia with anisocytosis, poikilocytosis, immature neutrophils, and nucleated red blood cells. The direct antiglobulin test result was positive, and the reticulocyte count was 1.39%. The patient had an uneventful recovery. However, reticulocytopenia persisted 1 month after discharge.

【 授权许可】

Unknown