Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia

São Paulo Medical Journal

Helena Zerlotti Wolf Grotto¹  Gisélia Aparecida Freire Maia de Lima¹ 

[1] Universidade Estadual de Campinas;

关键词: Soluble;    Transferrin;    Receptor;    Iron;    Deficiency;    Anemia;    Heterozygous;    Beta-thalassemia;    Reticulocytes;   

DOI  :  10.1590/S1516-31802003000200012

来源: DOAJ

【 摘 要 】

Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia. High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). There was no significant difference in high-fluorescence reticulocyte and soluble transferrin receptor values between the two groups, but a correlation was observed between high-fluorescence reticulocytes and soluble transferrin receptors in iron-deficiency anemia, probably due to increased receptor synthesis as a response to decreased iron content in erythrocytes.

【 授权许可】

Unknown