Soluble transferrin receptor and immature reticulocytes are not useful for distinguishing iron-deficiency anemia from heterozygous beta-thalassemia

Sao Paulo Medical Journal

Gisélia Aparecida Freire Maia De Lima¹  Helena Zerlotti Wolf Grotto¹ 

[1] ,Universidade de Campinas Faculdade de Ciências Médicas Department of Clinical PathologyCampinas São Paulo ,Brazil

关键词: Soluble;    Transferrin;    Receptor;    Iron;    Deficiency;    Anemia;    Heterozygous;    Beta-thalassemia;    Reticulocytes;    Receptor;    Solúvel;    Transferrina;    Anemia;    Ferropriva;    Beta-talassemia;    Heterozigótica;    Reticulócitos;   

DOI  :  10.1590/S1516-31802003000200012

来源: SciELO

【 摘 要 】

Iron deficiency and heterozygous beta-thalassemia are important causes of hypochromic-microcytic anemia. Two laboratory parameters are suggested for the differentiation of such anemia. High-fluorescence reticulocyte counts and soluble transferrin receptor levels were determined in iron-deficiency anemia patients (n = 49) and heterozygous beta-thalassemia patients (n = 43). There was no significant difference in high-fluorescence reticulocyte and soluble transferrin receptor values between the two groups, but a correlation was observed between high-fluorescence reticulocytes and soluble transferrin receptors in iron-deficiency anemia, probably due to increased receptor synthesis as a response to decreased iron content in erythrocytes.

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