Genome of Tetraploid Fish Schizothorax o'connori Provides Insights into Early Re-diploidization and High-Altitude Adaptation

iScience

Dingding Fan¹  Shilin Zhu²  Zhenbo Mou³  Yu Zou⁴  Wanliang Wang⁴  Ming Zou⁵  Yajuan Li⁵  Fei Liu⁶  Chaowei Zhou⁶  Ruibin Yang⁶  Yanchao Liu⁶  Haiping Liu⁷  Benhe Zeng⁷  Shijun Xiao⁷  He Zhou⁷  Hong Li⁷  Jiaqi Liu⁷  Di Wang⁷ 

[1] College of Plant Protection, Jilin Agriculture University, Changchun, Jilin, China;Department of Aquaculture, College of Animal Science, Southwest University, Chongqing, China;Department of Computer Science, Wuhan University of Technology, Wuhan, China;College of Fisheries and Life Science, Dalian Ocean University, Dalian, China;College of Fisheries, Huazhong Agricultural University, Wuhan, China;Department of Computer Science, Wuhan University of Technology, Wuhan, China;Institute of Fisheries Science, Tibet Academy of Agricultural and Animal Husbandry Sciences, Lhasa, China;

关键词: Biological Sciences;    Evolutionary Biology;    Genomics;    Transcriptomics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Whole-genome duplications (WGDs) of Schizothoracinae are believed to have played a significant role in speciation and environmental adaptation on the Qinghai-Tibet Plateau (QTP). Here, we present a genome for Schizothorax o'connori, a QTP endemic fish and showed the species as a young tetraploid with a recent WGD later than ∼1.23 mya. We exhibited that massive insertions between duplicated genomes caused by transposon bursts could induce mutagenesis in adjacent sequences and alter the expression of neighboring genes, representing an early re-diploidization process in a polyploid genome after WGD. Meanwhile, we found that many genes involved in DNA repair and folate transport/metabolism experienced natural selection and might contribute to the environmental adaptation of this species. Therefore, the S. o'connori genome could serve as a young tetraploid model for investigations of early re-diploidization in polyploid genomes and offers an invaluable genetic resource for environmental adaptation studies of the endemic fish of the QTP.

【 授权许可】

Unknown