Genome and Transcriptome Analyses of Vibrio vulnificus FORC_036 Isolated from a Surf Clam

Vibrio vulnificus;Food-borne pathogen;Genomics;Transcriptomics;Whole genome sequencing;RNA sequencing;Comparative genome analysis;630

농업생명과학대학 농생명공학부 ;

University:서울대학교 대학원

关键词: Vibrio vulnificus;    Food-borne pathogen;    Genomics;    Transcriptomics;    Whole genome sequencing;    RNA sequencing;    Comparative genome analysis;    630;   

Others  :  http://s-space.snu.ac.kr/bitstream/10371/125980/1/000000140628.pdf

美国|英语

来源: Seoul National University Open Repository

【 摘 要 】

(1) L-fucose utilization related genes and (2) thermostable hemolysin VPH-delta encoding gene.To figure out the transcriptional response when the strain FORC_036 was exposed to the model food (small octopus), RNA sequencing was conducted. The result showed that the expression of the motility related genes was down-regulated and the genes related to the adherence, galactose metabolism, and iron uptake were up-regulated. However, the expression of the toxin related genes was remained. Therefore, the strain FORC_036 recognized the small octopus as a reservoir rather than the host.All results described above demonstrated that V. vulnificus FORC_036 isolated from a surf clam was possibly pathogenic to human and used the small octopus as a reservoir to survive and grow. Through this study, the information of the pathogen isolated from environment was accumulated and it helps to deal with V. vulnificus-related outbreaks.