Microevolutionary Dynamics of Chicken Genomes under Divergent Selection for Adiposity

iScience

Yuxiang Wang¹  Xun Zhou¹  Xuming Zhou¹  Zhipeng Wang¹  Ruiqiang Li¹  Hui Li¹  Ning Wang¹  Zhiqiang Du²  Zhiquan Wang²  Qiqi Liang²  Hao Liang²  Yang Da²  Peng Luan²  Jie Mao²  Shouzhi Wang³  Jiyang Zhang⁴  Susan J. Lamont⁴  Hui Yuan⁴  Zhiping Cao⁴  Hui Zhang⁴  Li Leng⁴  Shilin Tian⁴  Qigui Wang⁵  Yumao Li⁵ 

[1] College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, P. R. China;Key Laboratory of Animal Genetics, Breeding and Reproduction, Education Department of Heilongjiang Province;Chongqing Academy of Animal Science, Chongqing 402460, P. R. China;Key Laboratory of Chicken Genetics and Breeding, Ministry of Agriculture and Rural Affairs;Novogene Bioinformatics Institute, Beijing 10089, P. R. China;

关键词: Biological Sciences;    Evolutionary Biology;    Genetics;    Genomics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Summary: Decades of artificial selection have significantly improved performance and efficiency of animal production systems. However, little is known about the microevolution of genomes due to intensive breeding. Using whole-genome sequencing, we document dynamic changes of chicken genomes under divergent selection on adiposity over 19 generations. Directional selection reduced within-line but increased between-line genomic differences. We observed that artificial selection tended to result in recruitment of preexisting variations of genes related to adipose tissue growth. In addition, novel mutations contributed to divergence of phenotypes under selection but contributed significantly less than preexisting genomic variants. Integration of 15 generations genome sequencing, genome-wide association study, and multi-omics data further identified that genes involved in signaling pathways important to adipogenesis, such as autophagy and lysosome (URI1, MBL2), neural system (CHAT), and endocrine (PCSK1) pathways, were under strong selection. Our study provides insights into the microevolutionary dynamics of domestic animal genomes under artificial selection.

【 授权许可】

Unknown