A new era of secreted phospholipase A2

Journal of Lipid Research

Yoshimi Miki¹  Hiroyasu Sato²  Kei Yamamoto³  Yoshitaka Taketomi⁴  Makoto Murakami⁵ 

[1] CREST, Japan Science and Technology Agency, Saitama 332-0012, Japan;Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;To whom correspondence should be addressed;Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan;To whom correspondence should be addressed;

关键词: arachidonic acid;    eicosanoids;    fatty acid;    immunology;    inflammation;    lipidomics;   

DOI  :  

来源: DOAJ

【 摘 要 】

Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca2+-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad. Individual sPLA2s exhibit unique tissue and cellular distributions and enzymatic properties, suggesting their distinct biological roles. Recent studies using transgenic and knockout mice for nearly a full set of sPLA2 subtypes, in combination with sophisticated lipidomics as well as biochemical and cell biological studies, have revealed distinct contributions of individual sPLA2s to various pathophysiological events, including production of pro- and anti-inflammatory lipid mediators, regulation of membrane remodeling, degradation of foreign phospholipids in microbes or food, or modification of extracellular noncellular lipid components. In this review, we highlight the current understanding of the in vivo functions of sPLA2s and the underlying lipid pathways as revealed by a series of studies over the last decade.

【 授权许可】

Unknown