期刊论文详细信息
Toxicology Reports
Genotoxicity assessment of food-flavoring chemicals used in Japan
Manabu Yasui1  Kei-ichi Sugiyama2  Masami Yamada3  Kenichi Masumura4  Masamitsu Honma4  Katsuyoshi Horibata4 
[1] Correspondence to: National Institute of Health Sciences, 3-25-26 Tonomachi, Kawasaki City, Kanagawa 210–9501, Japan.;Department of Applied Chemistry, National Defense Academy, Japan;Division of General Affairs, National Institute of Health Sciences, Japan;Division of Genetics and Mutagenesis, National Institute of Health Sciences, Japan;
关键词: Food flavors;    Genotoxicity;    Ames test;    Chromosomal aberration (CA) test;    Micronucleus (MN) test;    Transgenic mouse gene mutation (TG) assay;   
DOI  :  
来源: DOAJ
【 摘 要 】

We assessed the genotoxicity of 30 food-flavoring chemicals used in Japan that have not been investigated before. These 30 food-flavoring chemicals have representative chemical structures belonging to 18 chemical classes. The Ames and chromosomal aberration (CA) tests (in vitro tests) were first conducted in accordance with the “Food Additive Risk Assessment Guidelines” of the Japan Food Safety Commission. If the in vitro test yielded a positive result, an in vivo micronucleus test or a transgenic mouse gene mutation assay was performed to verify the in vitro test results. Of the 30 food-flavoring chemicals, 3 yielded a positive result in both Ames and CA tests. Another 11 chemicals yielded positive results in the CA test. However, none of the chemicals yielding positive in vitro test results yielded positive results in the in vivo tests. These findings indicate no genotoxicity concerns of the food-flavoring chemicals belonging to the abovementioned 18 chemical classes used in Japan unless there are other structural modifications.

【 授权许可】

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