Matrix metalloproteinases (MMPs) family gene polymorphisms and the risk of multiple sclerosis: systematic review and meta-analysis

BMC Neurology

Farhad Babaie¹  Bahman Razi²  Mina Mohammadhosayni³  Saeed Aslani⁴  Danyal Imani⁵  Shahram Torkamandi⁶  Arezou Khosrojerdi⁷  Keivan Lorian⁸ 

[1] Cellular and Molecular Research Center, Urmia University of Medical Sciences;Department of Hematology and Blood Transfusion, School of Medicine, Tarbiat Modares University;Department of Immunology, Faculty of Medicine, Shahed University;Department of Immunology, School of Medicine, Tehran University of Medical Sciences;Department of Immunology, School of Public Health, Tehran University of Medical Sciences;Department of Medical Genetics and Immunology, Faculty of Medicine, Urmia University of Medical Sciences;Department of Medical Immunology, Faculty of Medical Sciences, Tarbiat Modares University;Department of Physiology, School of Medicine, Tehran University of Medical Sciences (TUMS);

关键词: Multiple sclerosis;    Central nervous system;    Matrix metalloproteinases;    Genetic polymorphism;    Meta-analysis;   

DOI  :  10.1186/s12883-020-01804-2

来源: DOAJ

【 摘 要 】

Abstract Background Several studies have reported the association between polymorphisms in Matrix metalloproteinases (MMPs) gene family and risk of Multiple sclerosis (MS). However, the results have been inconsistent and inconclusive. To resolve this issue, here we performed a systematic review and meta-analysis of the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. Methods We conducted a comprehensive systematic search in the major electronic database, including Scopus and PubMed to look up for relevant studies published before December 2019 that surveyed the association between the MMP-91562 C/T (rs3918242), MMP-3 (− 1612 5A/6A), and MMP-2 (− 1306 C/T) polymorphisms and susceptibility to MS. The level of association between the polymorphisms and susceptibility to MS in the polled analysis was determined by calculating the odds ratio (OR) and the corresponding 95% confidence interval (CI). Results We found 15 studies containing 2430 MS subjects and 2304 controls. A statistically significant association was observed in the all five comparisons of the MMP-91562 C/T polymorphism and MS risk as follows: dominant model (OR = 1.62, 95% CI = 1.03–2.53, P = 0.03), recessive model (OR = 2.69, 95% CI = 1.68–4.29, P < 0.001), allelic model (OR = 1.51, 95% CI = 1–2.28, P = 0.04), TT vs. CC model (OR = 3.20, 95% CI = 1.87–5.46, P < 0.001), and CT vs. CC model (OR = 1.53, 95% CI = 1.02–2.28, P = 0.04). Conclusions Our meta-analysis revealed significant association of MMP-9 (− 1562 C/T) Single-nucleotide polymorphism (SNP) with MS susceptibility that increased the disease risk.

【 授权许可】

Unknown