Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis

BMC Nephrology

Xi Tang¹  Xiaolei Chen¹  Dutmanee Seriwatanachai²  Anchun Mo³  Megha Gupta⁴  Hanxiao Xue⁵  Qiuchan Xiong⁵  Xuedong Zhou⁵  Xiaobo Duan⁵  Yuqing Li⁵  Quan Yuan⁵  Dan Li⁵  Tong Xu⁵ 

[1] Department of Nephrology, West China Hospital, Sichuan University;Department of Oral Biology, Faculty of Dentistry, Mahidol University;Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University;Department of Preventive Dental Sciences, Division of Pedodontics, College of Dentistry, Al-Showajra Academic Campus, Jazan University;State Key Laboratory of Oral Diseases & National Clinical Research Centre for Oral Diseases, West China Hospital of Stomatology, Sichuan University;

关键词: Saliva;    Oral microbiome;    Hemodialysis;    Periodontal disease;   

DOI  :  10.1186/s12882-020-02009-y

来源: DOAJ

【 摘 要 】

Abstract Background Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investigate the periodontal status of HD patients and its relationship with salivary microbiome. Methods One hundred eight HD patients and one hundred healthy control individuals were recruited. They were subjected to periodontal examination followed by saliva samples collection for 16S rRNA gene sequencing. Results The HD patients were with worse periodontal health status, and exhibited higher salivary microbial diversity and lower richness. The periodontal pathogens were significantly enriched in the HD patients. The inferred functional analyze showed microbes enriched in the HD patients were mainly related to metabolism. Despite the periodontal status and overall structure of the microbiome were not significantly altered as the HD duration prolonged, the abundance of Lachnospiraceae [G-2] sp. |HMT_096| is positively correlated with the duration of HD and the community periodontal index (CPI). Five OTUs (operational taxonomic units) belonging to the phyla Firmicutes were enriched as the duration prolonged, and four OTUs originated from the phyla Proteobacteria were negatively related with the CPI index. ESRD patients undergoing HD exhibited microbiota structural, compositional and functional differences compared with the healthy controls. And the species changed as the duration of hemodialysis prolonged. Conclusions End stage renal disease changes salivary microbiome and is a risk factor for oral dysbiosis.

【 授权许可】

Unknown