Alzheimer’s disease, dementia, and stem cell therapy

Stem Cell Research & Therapy

Michael Valenzuela¹  Thomas Duncan¹ 

[1] Regenerative Neuroscience Group, Brain and Mind Centre & Sydney Medical School, University of Sydney;

关键词: Alzheimer’s disease;    Embryonic stem cells;    Induced pluripotent stem cells;    Mesenchymal stem cells;    Neural stem cells;   

DOI  :  10.1186/s13287-017-0567-5

来源: DOAJ

【 摘 要 】

Abstract Alzheimer’s disease (AD) represents arguably the most significant social, economic, and medical crisis of our time. Characterized by progressive neurodegenerative pathology, AD is first and foremost a condition of neuronal and synaptic loss. Repopulation and regeneration of depleted neuronal circuitry by exogenous stem cells is therefore a rational therapeutic strategy. This review will focus on recent advances in stem cell therapies utilizing animal models of AD, as well as detailing the human clinical trials of stem cell therapies for AD that are currently undergoing development.

【 授权许可】

Unknown