Self-help plus for refugees and asylum seekers; study protocol for a series of individual participant data meta-analyses

European Journal of Psychotraumatology

Ersin Uygun¹  Wietse A. Tol²  Daniel Lakin²  Jura Augustinavicius²  Marx Ronald Leku³  Ceren Acarturk⁴  Johannes Wancata⁵  Sarah Al-Hashimi⁵  Thomas Klein⁶  Markus Koesters⁶  Ross White⁷  Mariana Popa⁷  Maritta Välimäki⁸  Tella Lantta⁸  Minna Anttila⁸  Marianna Purgato⁹  Federico Tedeschi⁹  Corrado Barbui⁹  Emily Peckham^1,10  Della Bailey^1,10  Rachel Churchill^1,10  Eirini Karyotaki^1,11  Marit Sijbrandij^1,11  Pim Cuijpers^1,11  Teresa Au^1,12  Mark van Ommeren^1,12  Ken Carswell^1,12 

[1] Bilgi University;Bloomberg School of Public Health, Johns Hopkins University;HealthRight Uganda;Koc University;Medical University of Vienna;Ulm University;University of Liverpool;University of Turku;University of Verona;University of York;Vrije Universiteit Amsterdam;World Health Organization;

关键词: refugees;    asylum seekers;    individual participant data;    depression;    common mental disorders;   

DOI  :  10.1080/20008198.2021.1930690

来源: DOAJ

【 摘 要 】

Background Refugees and asylum seekers face various stressors due to displacement and are especially vulnerable to common mental disorders. To effectively manage psychological distress in this population, innovative interventions are required. The World Health Organization (WHO) Self-Help Plus (SH+) intervention has shown promising outcomes in reducing symptoms of common mental disorders among refugees and asylum seekers. However, individual participant differences in response to SH+ remain largely unknown. The Individual Participant Data (IPD) meta-analysis synthesizes raw datasets of trials to provide cutting-edge evidence of outcomes that cannot be examined by conventional meta-analytic approaches. Objectives This protocol outlines the methods of a series of IPD meta-analyses aimed at examining the effects and potential moderators of SH+ in (a) reducing depressive symptoms at post-intervention and (b) preventing the six-month cumulative incidence of mental disorders in refugees and asylum seekers. Method RCTs on SH+ have been identified through WHO and all authors have agreed to share the datasets of the trials. The primary outcomes of the IPD meta-analyses are (a) reduction in depressive symptoms at post-intervention, and (b) prevention of six-month cumulative incidence of mental disorders. Secondary outcomes include post-traumatic stress disorder symptoms, well-being, functioning, quality of life, and twelve-month cumulative incidence of mental disorders. One-stage IPD meta-analyses will be performed using mixed-effects linear/logistic regression. Missing data will be handled by multiple imputation. Conclusions These results will enrich current knowledge about the response to SH+ and will facilitate its targeted dissemination. The results of these IPD meta-analyses will be published in peer-reviewed journals.

【 授权许可】

Unknown