Hydrophobic@amphiphilic hybrid nanostructure of iron-oxide and graphene quantum dot surfactant as a theranostic platform

OpenNano

Mahdieh Ahmadi Kamalabadi¹  Fariborz Keyhanfar²  Saeideh Jafarinejad-Farsangi³  Elham Jafari⁴  Zahra Miri Karam⁵  Amin Shiralizadeh Dezfuli⁶  Azita Aliakbarniya⁷  Maedeh Koohi⁸  Sepand Tehrani Fateh⁹ 

[1] Ronash Technology Pars Company, Tehran, Iran;Cardiovascular Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;Department of Biology, Faculty of Life Sciences, Tonekabon Branch, Islamic Azad University, Mazandaran, Iran;Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran;Department of Pathology, Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran;Department of Pharmacology, Faculty of Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran;Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran;Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran;School of Medicine, Shahid Beheshti University of Medical Sciences (SBMU), Tehran, Iran;

关键词: Theranostics;    Magnetic nanoparticles;    Graphene quantum dots;    Surfactant;    Hybrid nanomaterials;   

DOI  :  

来源: DOAJ

【 摘 要 】

Nanostructure hybrids offer exceptional properties and multifunctionality, suitable for the field of theranostics. Graphene quantum dots (GQDs) and magnetic nanoparticles (MNPs) are two possible candidates to be used these hybrids due to their chemical, physical and biological properties. GQDs can be modified to act as surfactants. In this study, a hybrid nanostructure of GQDs and MNP has been synthesized based on hydrophobic interactions between long carbon chains on the surface of GQDs on the surroundings and MNP at the center. We have synthesized GQDs through a pyrolysis process and modified them with cetyl alcohol to obtain a surfactant-GQDs (CAGQDs). Moreover, Iron-oxide nanoparticles (IONP) as MNP has been synthesized using oleate-iron complex. Afterward, CAGQDs and IONP are hybridized, leading to a structure in which IONP is located at the center, and it is surrounded by CAGQDs (IONP@CAGQD). IONP@CAGQD possesses fluorescent and magnetic properties. Moreover, hydrophobic and hydrophilic cargo loading abilities, contrast enhancement, targeting abilities, and stimuli-responsiveness are other features of this structure. Furthermore, Low cytotoxicity of IONP@CAGQD makes its biomedical applications possible. IONP@CAGQD can potentially be used as a multifunctional theranostic agent.

【 授权许可】

Unknown