Magnetic nanoparticles in theranostics of malignant melanoma

EJNMMI Research

卷:11

Maxim Shevtsov¹  Gabriele Multhoff¹  Christian Posch²  Susanne Kaesler²  Tilo Biedermann² 

[1] Central Institute for Translational Cancer Research (TranslaTUM), Radiation Immuno-Oncology Group, Klinikum rechts der Isar, School of Medicine, Technical University Munich (TUM);

[2] Department of Dermatology and Allergology, Klinikum rechts der Isar, School of Medicine, Technical University Munich (TUM);

关键词: Melanoma;    Magnetic nanoparticles;    SPIONs;    Theranostics;   

DOI  :  10.1186/s13550-021-00868-6

来源: DOAJ

【 摘 要 】

Abstract Malignant melanoma is an aggressive tumor with a tendency to metastasize early and with an increasing incidence worldwide. Although in early stage, melanoma is well treatable by excision, the chances of cure and thus the survival rate decrease dramatically after metastatic spread. Conventional treatment options for advanced disease include surgical resection of metastases, chemotherapy, radiation, targeted therapy and immunotherapy. Today, targeted kinase inhibitors and immune checkpoint blockers have for the most part replaced less effective chemotherapies. Magnetic nanoparticles as novel agents for theranostic purposes have great potential in the treatment of metastatic melanoma. In the present review, we provide a brief overview of treatment options for malignant melanoma with different magnetic nanocarriers for theranostics. We also discuss current efforts of designing magnetic particles for combined, multimodal therapies (e.g., chemotherapy, immunotherapy) for malignant melanoma.

【 授权许可】

Unknown