Role of Autophagy in Cancer Cell Response to Nucleolar and Endoplasmic Reticulum Stress

International Journal of Molecular Sciences

Giulia Russo¹  Martina Pagano¹  Annalisa Pecoraro¹  Annapina Russo¹ 

[1] Department of Pharmacy, University of Naples “Federico II”, Via Domenico Montesano 49, 80131 Naples, Italy;

关键词: nucleolar stress;    autophagy;    ribosomal proteins;    endoplasmic reticulum stress;   

DOI  :  10.3390/ijms21197334

来源: DOAJ

【 摘 要 】

Eukaryotic cells are exposed to many internal and external stimuli that affect their fate. In particular, the exposure to some of these stimuli induces stress triggering a variety of stress responses aimed to re-establish cellular homeostasis. It is now established that the deregulation of stress response pathways plays a central role in cancer initiation and progression, allowing the adaptation of cells to an altered state in the new environment. Autophagy is a tightly regulated pathway which exerts “housekeeping” role in physiological processes. Recently, a growing amount of evidence highlighted the crucial role of autophagy in the regulation of integrated stress responses, including nucleolar and endoplasmic reticulum. In this review, we attempt to afford an overview of the complex role of nucleolar and endoplasmic reticulum stress-response mechanisms in the regulation of autophagy in cancer and cancer treatment.

【 授权许可】

Unknown